TL;DR: The answer to the question in the title is most likely “no.” While the OPAQUE protocol is a fascinating approach to authentication, for web applications it doesn’t provide any security advantages.
I read an interesting post by Matthew Green where he presents ways to authenticate users by password without actually transmitting the password to the server, in particular a protocol called OPAQUE. It works roughly like that:
The server has the user’s salt and public key, the client knows the password. Through application of some highly advanced magic, a private key materializes in the client, matching the public key known to the server. This only works if the password known to the client is correct, yet the client doesn’t learn the salt and the server doesn’t learn the password in the process. From that point on, the client can sign any requests sent to the server, and the server can verify them as belonging to this user.